Temporal Variation in Selection Accelerates Mutational Decay by Muller’s Ratchet
نویسندگان
چکیده
منابع مشابه
Temporal variation in selection accelerates mutational decay by Muller's ratchet.
Asexual species accumulate deleterious mutations through an irreversible process known as Muller's ratchet. Attempts to quantify the rate of the ratchet have ignored the role of temporal environmental heterogeneity even though it is common in nature and has the potential to affect overall ratchet rate. Here we examine Muller's ratchet in the context of conditional neutrality (i.e., mutations th...
متن کاملMutational Meltdown in Primary Endosymbionts: Selection Limits Muller's Ratchet
BACKGROUND Primary bacterial endosymbionts of insects (p-endosymbionts) are thought to be undergoing the process of Muller's ratchet where they accrue slightly deleterious mutations due to genetic drift in small populations with negligible recombination rates. If this process were to go unchecked over time, theory predicts mutational meltdown and eventual extinction. Although genome degradation...
متن کاملMuller's Ratchet and Mutational Meltdowns.
We extend our earlier work on the role of deleterious mutations in the extinction of obligately asexual populations. First, we develop analytical models for mutation accumulation that obviate the need for time-consuming computer simulations in certain ranges of the parameter space. When the number of mutations entering the population each generation is fairly high, the number of mutations per i...
متن کاملWeak temporal ratchet effect by asymmetric modulation of a laser.
Subjecting lasers to triangular modulations of the pump produces phenomena that drastically depend on the symmetry of the triangle. For instance, with slow up-rising triangles, a laser below threshold on average may deliver coherent pulses, while it does not deliver coherent pulses with fast up-rising triangles. This effect, which requires the presence of fluctuations in addition to the modulat...
متن کاملVariations in Variation and Selection: the Ubiquity of the Variation-and-selective-retention Ratchet in Emergent Organizational Complexity
The variation and selection form of explanation can be prescinded from the evolutionary biology home ground in which it was discovered and for which it has been most developed. When this is done, variation and selection explanations are found to have potential application to a wide range of phenomena, far beyond the classical biological ground and the contemporary extensions into epistemologica...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genetics
سال: 2012
ISSN: 1943-2631
DOI: 10.1534/genetics.112.140962